Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209946 | 1.00 | NPC1 (0.44) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9207807 | 1.00 | NPC1 (0.44) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9200999 | 0.80 | NPC1 (0.46) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL9203728 | 0.74 | NPC1 (0.46) | NPC1ALDH1A1GAAMAPTL3MBTL1 | |
| SCHEMBL9200737 | 0.71 | NPC1 (0.42) | NPC1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL9200733 | 0.71 | NPC1 (0.42) | NPC1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL30589095 | 0.70 | NPC1 (0.46) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL30589030 | 0.70 | NPC1 (0.46) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL21828523 | 0.70 | NPC1 (0.46) | NPC1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL844250 | 0.70 | SIGMAR1 (0.48) | ALDH1A1MAPTL3MBTL1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561941-B1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | SEARLE & CO (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5314886-A | N-substituted lactams useful as cholecystokinin antagonists | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | disclosed |
| US-5202344-A | Disorders of the gastrointestinal, central nervous system and appetite regulatory systems | G. D. SEARLE & CO. (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1992010476-A1 | N-SUBSTITUTED LACTAMS USEFUL AS CHOLECYSTOKININ ANTAGONISTS | G.D. SEARLE & CO. (US) | 1992-06-25 | — | — | WO | disclosed |