Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202252 | 0.85 | CYP17A1 (0.48) | CYP19A1CYP11B1CYP11B2KMT2APOLB | |
| SCHEMBL11187671 | 0.84 | CYP11B1 (0.55) | CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11020035 | 0.79 | CYP11B1 (0.49) | CYP19A1CYP11B1CYP11B2KMT2AHMOX1 | |
| SCHEMBL9202374 | 0.78 | CYP11B1 (0.45) | CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11198093 | 0.78 | CYP11B1 (0.40) | CYP19A1CYP11B1CYP11B2HMOX1MAPK1 | |
| SCHEMBL9201200 | 0.78 | CYP11B1 (0.56) | CYP19A1CYP11B1CYP11B2KMT2A | |
| SCHEMBL11265991 | 0.77 | CYP11B1 (0.75) | CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL11273678 | 0.76 | CYP17A1 (0.50) | CYP19A1CYP11B1CYP11B2POLB | |
| SCHEMBL11079276 | 0.76 | CYP19A1 (0.49) | CYP19A1CYP11B1CYP11B2KMT2APOLB | |
| SCHEMBL9200864 | 0.76 | CYP19A1 (0.58) | CYP19A1CYP11B1CYP11B2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513149-B1 | PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY | DU PONT MERCK PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0354539-B1 | Antiinflammatory carbinoloimidazoles | DU PONT MERCK PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0513149-A1 | PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY. | DU PONT MERCK PHARMA (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1991011445-A1 | PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |
| EP-0354539-A2 | Antiinflammatory carbinoloimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-02-14 | — | — | EP | disclosed |
| US-4859693-A | Antiinflammatory carbinoloimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-22 | — | — | US | disclosed |