Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | QPCT | Q16769 | 2/20 | 0.51 |
| ▸ | NOS1 | P29475 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11640934 | 0.86 | CYP19A1 (0.56) | CYP19A1POLBQPCTNOS1CYP11B1 | |
| SCHEMBL11492895 | 0.77 | CYP17A1 (0.53) | CYP19A1POLBQPCTCYP11B1CYP11B2 | |
| SCHEMBL9200907 | 0.76 | CYP19A1 (0.48) | CYP19A1POLBCYP11B1CYP11B2KMT2A | |
| SCHEMBL9202252 | 0.75 | CYP17A1 (0.48) | CYP19A1POLBQPCTCYP11B1CYP11B2 | |
| SCHEMBL11187671 | 0.74 | CYP11B1 (0.55) | CYP19A1QPCTCYP11B1CYP11B2KMT2A | |
| SCHEMBL11005198 | 0.74 | CYP19A1 (0.46) | CYP19A1POLBQPCTCYP11B1CYP11B2 | |
| SCHEMBL11495476 | 0.74 | POLB (0.49) | CYP19A1POLBNOS1CYP11B1CYP11B2 | |
| SCHEMBL11631856 | 0.72 | CYP19A1 (0.67) | CYP19A1POLBQPCTCYP11B1CYP11B2 | |
| SCHEMBL11643688 | 0.72 | CYP19A1 (0.56) | CYP19A1POLBQPCTCYP11B1CYP11B2 | |
| SCHEMBL8684902 | 0.72 | QPCT (0.73) | POLBQPCTNOS1TBXAS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354539-B1 | Antiinflammatory carbinoloimidazoles | DU PONT MERCK PHARMA (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0354539-A2 | Antiinflammatory carbinoloimidazoles | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-02-14 | — | — | EP | disclosed |
| US-4859693-A | Antiinflammatory carbinoloimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-22 | — | — | US | disclosed |