Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9282708 | 0.89 | SIGMAR1 (0.56) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9202636 | 0.88 | SIGMAR1 (0.55) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9209267 | 0.88 | SIGMAR1 (0.60) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9204730 | 0.86 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2A | |
| Oxalic Acid SCHEMBL9203704 | 0.86 | SIGMAR1 (0.62) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9274045 | 0.85 | SIGMAR1 (0.46) | SIGMAR1MEN1ALDH1A1KMT2A | |
| Oxalic Acid SCHEMBL9205537 | 0.85 | SIGMAR1 (0.66) | SIGMAR1 | |
| Oxalic Acid SCHEMBL9277534 | 0.85 | NMT2 (0.50) | SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL9209143 | 0.84 | SIGMAR1 (0.50) | SIGMAR1MEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL9199403 | 0.84 | SIGMAR1 (0.49) | SIGMAR1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430693-B1 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-31 | — | — | EP | disclosed |
| US-5114941-A | PYRIMIDINEDIONE DERIVATIVE COMPOUNDS, METHOD FOR PREPARING SAME, AND ANTIARRYTHMIC AGENTS CONTAINING SAME | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0430693-A2 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-06-05 | — | — | EP | disclosed |