Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 12/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195045 | 0.85 | ABCB1 (0.46) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL6559220 | 0.80 | ABCB1 (0.46) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL9195542 | 0.76 | ABCC9 (0.41) | ABCB1CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL9200651 | 0.74 | ABCB1 (0.44) | ABCB1KCNE1KCNQ1KDM4EABCC9 | |
| SCHEMBL8538245 | 0.74 | ABCB1 (0.46) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL9740322 | 0.74 | ABCB1 (0.39) | ABCB1CYP1A2CYP2D6CYP2C19ABCC9 | |
| SCHEMBL9735474 | 0.72 | ABCB1 (0.41) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL9198669 | 0.72 | MAOB (0.44) | ABCB1KMT2AKDM4E | |
| SCHEMBL8534900 | 0.70 | ABCB1 (0.41) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL8535501 | 0.70 | ABCB1 (0.41) | ABCB1KCNE1KCNQ1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415065-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1995-06-28 | — | — | EP | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |