Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9443553 | 0.81 | KDM4E (0.46) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL7267968 | 0.81 | KDM4E (0.46) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9443453 | 0.81 | KDM4E (0.46) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9736053 | 0.81 | HTR2B (0.32) | — | |
| SCHEMBL9443496 | 0.79 | KCNE1 (0.46) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9443533 | 0.74 | ABCB1 (0.43) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9443538 | 0.74 | KCNE1 (0.45) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9443526 | 0.73 | ABCB1 (0.42) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9443535 | 0.73 | KCNE1 (0.44) | ABCB1KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9200651 | 0.72 | ABCB1 (0.44) | ABCB1KCNE1KCNQ1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |