Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207611 | 0.84 | AKR1B1 (0.54) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9199064 | 0.71 | AKR1B1 (0.67) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9209897 | 0.70 | AKR1B1 (0.85) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9205172 | 0.69 | AKR1B1 (0.62) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9870990 | 0.68 | AKR1B1 (0.62) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL29303320 | 0.67 | CYP1A2 (0.57) | AKR1B1MEN1CYP1A2KMT2ACHRM5 | |
| SCHEMBL30975681 | 0.67 | CYP1A2 (0.57) | AKR1B1MEN1CYP1A2KMT2ACHRM5 | |
| SCHEMBL1045552 | 0.66 | POLB (0.43) | MEN1KMT2AGRM2MAPT | |
| SCHEMBL9872250 | 0.66 | AKR1B1 (0.57) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL6101025 | 0.65 | CHRM5 (0.46) | AKR1B1MEN1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401981-B1 | Pyridazinone deriratives | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |