Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205172 | 0.92 | AKR1B1 (0.62) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9870990 | 0.88 | AKR1B1 (0.62) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9872250 | 0.81 | AKR1B1 (0.57) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9209897 | 0.77 | AKR1B1 (0.85) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9206818 | 0.72 | AKR1B1 (0.57) | AKR1B1MEN1KMT2ABRD4 | |
| SCHEMBL9201378 | 0.71 | AKR1B1 (0.57) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9204791 | 0.70 | AKR1B1 (0.71) | AKR1B1 | |
| SCHEMBL11165597 | 0.69 | AKR1B1 (0.77) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL9207611 | 0.69 | AKR1B1 (0.54) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| Ponalrestat SCHEMBL49154 | 0.68 | AKR1B1 (1.00) | AKR1B1MEN1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401981-B1 | Pyridazinone deriratives | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |