Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870990 | 0.93 | AKR1B1 (0.62) | AKR1B1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9205172 | 0.88 | AKR1B1 (0.62) | AKR1B1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9870150 | 0.81 | AKR1B1 (0.54) | AKR1B1MEN1KMT2A | |
| SCHEMBL9199064 | 0.81 | AKR1B1 (0.67) | AKR1B1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9209897 | 0.77 | AKR1B1 (0.85) | AKR1B1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9871499 | 0.77 | AKR1B1 (0.65) | AKR1B1 | |
| SCHEMBL9872192 | 0.76 | AKR1B1 (0.54) | AKR1B1 | |
| SCHEMBL9870643 | 0.73 | AKR1B1 (0.52) | AKR1B1KDM4E | |
| SCHEMBL9870131 | 0.73 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9870079 | 0.71 | AKR1B1 (0.36) | AKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996204-A | Antidiabetic agents | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0401981-A1 | Pyridazinone deriratives | PFIZER INC. (US) | 1990-12-12 | — | — | EP | disclosed |