Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 3/20 | 0.70 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.63 |
| ▸ | MARS1 | P56192 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 3/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 2/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207663 | 0.94 | RPA1 (0.62) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL14505025 | 0.91 | RPA1 (0.59) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL9199063 | 0.91 | CHRNA7 (0.66) | RPA1MALT1CHRNA7PTGS2PTGS1 | |
| SCHEMBL6351220 | 0.91 | CHRNA7 (0.78) | CHRNA7PTGS2PTGS1CA1CA2 | |
| SCHEMBL14504642 | 0.89 | RPA1 (0.58) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL9201580 | 0.89 | CA9 (0.59) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL6208270 | 0.89 | RPA1 (0.57) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL9056282 | 0.87 | RPA1 (0.90) | RPA1MALT1CHRNA7MARS1BCL2 | |
| SCHEMBL27224492 | 0.87 | RPA1 (0.55) | RPA1MALT1CHRNA7MARS1FAAH | |
| SCHEMBL5152432 | 0.87 | RPA1 (0.60) | RPA1MALT1CHRNA7MARS1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |