Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.59 |
| ▸ | RPA1 | P27694 | 3/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MARS1 | P56192 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27333015 | 0.90 | RPA1 (0.72) | CA9RPA1CHRNA7MALT1PTGS2 | |
| SCHEMBL9201508 | 0.89 | RPA1 (0.70) | CA9RPA1CHRNA7MALT1PTGS2 | |
| SCHEMBL9207779 | 0.85 | CA9 (0.75) | CA9RPA1CHRNA7MALT1PTGS2 | |
| SCHEMBL5698731 | 0.85 | PTGS1 (0.65) | CA9RPA1CHRNA7PTGS2PTGS1 | |
| SCHEMBL9201561 | 0.84 | CA9 (0.59) | CA9RPA1CHRNA7MALT1PTGS2 | |
| SCHEMBL9207663 | 0.84 | RPA1 (0.62) | RPA1CHRNA7MALT1PTGS2PTGS1 | |
| SCHEMBL6353551 | 0.83 | CA9 (0.82) | CA9CHRNA7PTGS2PTGS1CA1 | |
| SCHEMBL6351220 | 0.83 | CHRNA7 (0.78) | CA9CHRNA7PTGS2PTGS1CA1 | |
| SCHEMBL9199063 | 0.83 | CHRNA7 (0.66) | CA9RPA1CHRNA7MALT1PTGS2 | |
| SCHEMBL7239500 | 0.82 | MAPT (0.59) | CA9PTGS2PTGS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |