Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9323695 | 0.82 | AKR1B1 (0.43) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL1748051 | 0.76 | AKR1B1 (0.37) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8400483 | 0.74 | AKR1B1 (0.44) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8395489 | 0.73 | AKR1B1 (0.39) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8399351 | 0.72 | AKR1B1 (0.46) | AKR1B1RAB9AMAPT | |
| SCHEMBL1748005 | 0.72 | SMN1; SMN2 (0.47) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL30389176 | 0.72 | SMN1; SMN2 (0.47) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL3661945 | 0.72 | AKR1B1 (0.36) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL25604130 | 0.72 | SMN1; SMN2 (0.42) | AKR1B1RAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8395800 | 0.72 | AKR1B1 (0.41) | AKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401981-B1 | Pyridazinone deriratives | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-4996204-A | Antidiabetic agents | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0401981-A1 | Pyridazinone deriratives | PFIZER INC. (US) | 1990-12-12 | — | — | EP | disclosed |