Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.71 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15463064 | 0.86 | ALOX5 (0.73) | PTGS2PTGS1CYP2C9ALOX5 | |
| SCHEMBL8421061 | 0.85 | PTGS2 (0.88) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL9203342 | 0.85 | PTGS2 (0.73) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL14280456 | 0.85 | ALOX5 (0.76) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL9207256 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL28740979 | 0.84 | PTGS2 (0.71) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL9210255 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1AOC3CYP2C9ALOX5 | |
| SCHEMBL5229949 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9ALOX5 | |
| Sc-58125 SCHEMBL12375146 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9ALOX5 | |
| Sc-58125 SCHEMBL214120 | 0.83 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |