Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | MARS1 | P56192 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693715 | 0.89 | CHRNA7 (0.61) | PDE4BCHRNA7CA9FAAHMARS1 | |
| SCHEMBL15456724 | 0.89 | CA9 (0.60) | PDE4BCHRNA7CA9FAAHMARS1 | |
| SCHEMBL9206389 | 0.85 | CA9 (0.64) | CHRNA7CA9FAAHGAAKMT2A | |
| SCHEMBL9208211 | 0.84 | CA9 (0.52) | CHRNA7CA9FAAHALDH1A1GAA | |
| SCHEMBL9207624 | 0.84 | MARS1 (0.49) | MARS1ALDH1A1KMT2ARXRANR1H2 | |
| SCHEMBL9201539 | 0.81 | CA9 (0.70) | CHRNA7CA9FAAHRPA1 | |
| SCHEMBL9206790 | 0.80 | CHRNA7 (0.54) | CHRNA7CA9FAAHMARS1ALDH1A1 | |
| SCHEMBL9205210 | 0.80 | CHRNA7 (0.54) | CHRNA7CA9FAAHMARS1ALDH1A1 | |
| SCHEMBL342100 | 0.80 | MARS1 (0.68) | CHRNA7CA9FAAHMARS1LMNA | |
| SCHEMBL29419099 | 0.80 | MARS1 (0.68) | CHRNA7CA9FAAHMARS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |