Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701625 | 0.84 | KDM4E (0.62) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3203944 | 0.84 | KDM4E (0.70) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL48869 | 0.81 | POLB (0.60) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL10444949 | 0.79 | TBXAS1 (0.64) | TBXA2RTBXAS1 | |
| SCHEMBL10444950 | 0.79 | TBXAS1 (0.64) | TBXA2RTBXAS1 | |
| SCHEMBL8884783 | 0.79 | TBXAS1 (0.68) | TBXA2RTBXAS1 | |
| SCHEMBL8884779 | 0.79 | TBXAS1 (0.68) | TBXA2RTBXAS1 | |
| SCHEMBL10829884 | 0.78 | SMN1; SMN2 (0.64) | KMT2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL8882471 | 0.78 | TBXAS1 (0.77) | TBXA2RTBXAS1 | |
| SCHEMBL8882467 | 0.78 | TBXAS1 (0.77) | TBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397044-B1 | Arylsulfonamides, medicines containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1995-12-27 | — | — | EP | disclosed |
| EP-0397044-A2 | Arylsulfonamides, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-11-14 | — | — | EP | disclosed |