Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388813 | 0.85 | DRD2 (0.55) | SIGMAR1DRD2DRD4DRD3MCHR1 | |
| SCHEMBL1388300 | 0.84 | DRD2 (0.56) | SIGMAR1DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL9202150 | 0.82 | DRD2 (0.57) | DRD2DRD4DRD3GAAALDH1A1 | |
| SCHEMBL6530769 | 0.80 | HTT (0.53) | SIGMAR1DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL1388432 | 0.79 | DRD4 (0.54) | DRD2DRD4DRD3ALDH1A1KDM4E | |
| SCHEMBL9199928 | 0.78 | MEN1 (0.60) | DRD2DRD4DRD3GAAALDH1A1 | |
| SCHEMBL9195743 | 0.76 | DRD2 (0.55) | DRD2DRD4DRD3TSHRALDH1A1 | |
| SCHEMBL1388769 | 0.75 | DRD2 (0.56) | SIGMAR1DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL1388576 | 0.75 | DRD2 (0.56) | SIGMAR1DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL29905453 | 0.75 | MCHR1 (0.47) | SIGMAR1DRD2DRD4DRD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665833-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-09 | — | — | EP | disclosed |