Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388432 | 0.87 | DRD4 (0.54) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL1388639 | 0.80 | DRD2 (0.70) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL1528409 | 0.80 | HSD17B10 (0.60) | MEN1KMT2AGAAALPLALDH1A1 | |
| SCHEMBL9202145 | 0.78 | SIGMAR1 (0.55) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL1388300 | 0.77 | DRD2 (0.56) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL9199936 | 0.76 | HSD17B10 (0.44) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL9195743 | 0.75 | DRD2 (0.55) | DRD2DRD4DRD3BCHETP53 | |
| SCHEMBL9202150 | 0.73 | DRD2 (0.57) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL1388610 | 0.72 | DRD2 (0.56) | KMT2ADRD2DRD4DRD3ACHE | |
| SCHEMBL9195679 | 0.72 | DRD2 (0.52) | MEN1KMT2ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665833-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-09 | — | — | EP | disclosed |