Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201885 | 0.89 | CYSLTR1 (0.52) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9203602 | 0.87 | GPBAR1 (0.60) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9199452 | 0.87 | GPBAR1 (0.59) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9207173 | 0.83 | CYSLTR1 (0.59) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9201884 | 0.82 | PDE10A (0.50) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9273829 | 0.81 | PDE10A (0.48) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9202041 | 0.80 | ALOX5AP (0.55) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9202068 | 0.79 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL9209065 | 0.79 | CYSLTR1 (0.63) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9199593 | 0.77 | CYSLTR1 (0.56) | PDE10ACYSLTR1GPBAR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |