Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209194 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2ALOX5CYP1A2PDE10A | |
| SCHEMBL9207173 | 0.87 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9199452 | 0.85 | GPBAR1 (0.59) | CYSLTR1CYSLTR2CYP1A2PDE10AGPBAR1 | |
| SCHEMBL9200310 | 0.83 | SRD5A2 (0.53) | PPARGPPARDPPARA | |
| SCHEMBL9203602 | 0.81 | GPBAR1 (0.60) | CYSLTR1CYSLTR2ALOX5CYP1A2PDE10A | |
| SCHEMBL9201885 | 0.81 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2CYP1A2PDE10AGPBAR1 | |
| SCHEMBL9209060 | 0.80 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2ALOX5CYP1A2PDE10A | |
| SCHEMBL9202170 | 0.79 | PDE10A (0.52) | CYSLTR1CYSLTR2CYP1A2PDE10AGPBAR1 | |
| SCHEMBL9202068 | 0.78 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL14021499 | 0.78 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2ALOX5PDE10AGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637298-A1 | SUBSTITUTED CYCLOHEXENE-1,2-BICARBOXYLIC ACID DERIVATIVES AND RAW MATERIALS FOR PRODUCING THEM | BASF Aktiengesellschaft (DE) | 1995-02-08 | — | — | EP | claimed |
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |