Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 6/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203849 | 0.85 | TDP2 (0.43) | CACNA1CTDP2MAPTKMT2AALDH1A1 | |
| SCHEMBL9568083 | 0.81 | MAPT (0.50) | CACNA1CMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL30398320 | 0.81 | MAPT (0.50) | CACNA1CMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL9203839 | 0.79 | TDP2 (0.43) | CACNA1CTDP2MAPTKMT2AALDH1A1 | |
| SCHEMBL13405570 | 0.76 | CACNA1C (0.41) | CACNA1CMAPTKMT2ACACNA1DCACNA1F | |
| SCHEMBL28087596 | 0.75 | ALDH1A1 (0.56) | TDP2MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL9202279 | 0.74 | GSK3B (0.48) | CACNA1CTDP2MAPTKMT2ACACNA1D | |
| SCHEMBL9204538 | 0.74 | TDP2 (0.46) | CACNA1CTDP2MAPTKMT2ACACNA1D | |
| SCHEMBL8948751 | 0.71 | MAPT (0.43) | CACNA1CMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL6974946 | 0.71 | MAPT (0.40) | CACNA1CMAPTKMT2ACACNA1DCACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459561-B1 | Dioxo-tetrahydroquinoline derivatives | MERCK SHARP & DOHME (GB) | 1995-09-20 | — | — | EP | claimed |