Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204222 | 0.93 | LMNA (0.53) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL1439677 | 0.91 | LMNA (0.57) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL13853971 | 0.90 | HTT (0.58) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL13854151 | 0.85 | HTT (0.54) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL2402780 | 0.84 | HTT (0.74) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL13725441 | 0.84 | HTT (0.59) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL16558067 | 0.83 | HTT (0.65) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL1299850 | 0.83 | HTT (0.72) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL7282990 | 0.82 | HSD17B10 (0.56) | HTTLMNASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL6223210 | 0.82 | HTT (0.67) | HTTLMNASMN1; SMN2TGM2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496561-B1 | [[(2-Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives | AMERICAN HOME PROD (US) | 1995-03-15 | — | — | EP | disclosed |
| US-5240946-A | Anticonvulsants, nervous system disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-31 | — | — | US | disclosed |
| US-5168103-A | Neuroprotectants, anticonvulsants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-01 | — | — | US | disclosed |
| EP-0496561-A2 | [[(2-Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-29 | — | — | EP | disclosed |