Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 17/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9202909 | 1.00 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL7903137 | 0.97 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL7903132 | 0.97 | ACHE (0.91) | ACHE | |
| SCHEMBL7229437 | 0.95 | ACHE (1.00) | ACHE | |
| Fumaric Acid SCHEMBL9201729 | 0.93 | ACHE (0.91) | ACHE | |
| Fumaric Acid SCHEMBL9201722 | 0.93 | ACHE (0.91) | ACHE | |
| SCHEMBL12043722 | 0.93 | ACHE (1.00) | ACHE | |
| SCHEMBL12043720 | 0.92 | ACHE (0.98) | ACHE | |
| Fumaric Acid SCHEMBL9210143 | 0.91 | ACHE (0.86) | ACHE | |
| Fumaric Acid SCHEMBL9210135 | 0.91 | ACHE (0.86) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487071-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5273974-A | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-28 | — | — | US | disclosed |
| EP-0487071-A1 | Condensed heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-05-27 | — | — | EP | disclosed |