Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.60 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207687 | 0.86 | CYSLTR1 (0.59) | CYSLTR1GPBAR1CYSLTR2NR4A2NR4A1 | |
| SCHEMBL9206569 | 0.85 | MAOB (0.62) | CYSLTR1GPBAR1CYSLTR2NR4A2NR4A1 | |
| SCHEMBL9201308 | 0.85 | CYSLTR1 (0.55) | CYSLTR1GPBAR1CYSLTR2NR4A2 | |
| SCHEMBL9207699 | 0.82 | PLA2G2A (0.47) | CYSLTR1CYSLTR2 | |
| SCHEMBL10638941 | 0.80 | CYSLTR1 (0.74) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9205351 | 0.79 | CYSLTR1 (0.63) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10632363 | 0.78 | CYSLTR1 (0.71) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL10638668 | 0.78 | CYSLTR1 (0.71) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9054057 | 0.78 | NPC1 (0.55) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9259437 | 0.77 | CYSLTR2 (0.51) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399818-B1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC (CA) | 1995-08-16 | — | — | EP | disclosed |
| US-5204358-A | Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5104882-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-04-14 | — | — | US | disclosed |
| EP-0399818-A1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC. (CA) | 1990-11-28 | — | — | EP | disclosed |