Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14272575 | 0.91 | LTB4R (0.44) | PLA2G2ALTB4RCYP4F2CYP4A11CYSLTR1 | |
| SCHEMBL9210323 | 0.85 | LTB4R (0.49) | PLA2G2ALTB4RKDM4E | |
| SCHEMBL14272573 | 0.83 | CCR2 (0.47) | PLA2G2ALTB4RCYSLTR1 | |
| SCHEMBL9203644 | 0.82 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2 | |
| SCHEMBL9202903 | 0.78 | PLA2G2A (0.45) | PLA2G2ALTB4RCYP4F2CYP4A11CYSLTR1 | |
| SCHEMBL9202908 | 0.78 | PLA2G2A (0.45) | PLA2G2ALTB4RCYP4F2CYP4A11CYSLTR1 | |
| SCHEMBL4416755 | 0.75 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL4416752 | 0.75 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL9339023 | 0.75 | GPBAR1 (0.45) | PLA2G2ACYSLTR1 | |
| SCHEMBL2057210 | 0.74 | ERCC5 (0.63) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399818-B1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC (CA) | 1995-08-16 | — | — | EP | disclosed |
| US-5204358-A | Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5104882-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-04-14 | — | — | US | disclosed |
| EP-0399818-A1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC. (CA) | 1990-11-28 | — | — | EP | disclosed |