Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA5A | P35218 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7396037 | 0.82 | HRH1 (0.52) | CA2CA1CA9CA5AHRH1 | |
| SCHEMBL12497701 | 0.78 | GBA1 (0.47) | CA2CA1CA9CA5AGBA1 | |
| SCHEMBL22042211 | 0.76 | HRH1 (0.46) | HRH1CES2CES1HTR2ATAAR1 | |
| SCHEMBL3129679 | 0.74 | SRC (0.39) | HRH1CES2CES1HTR2ACYP2C19 | |
| SCHEMBL4061139 | 0.72 | CYP2D6 (0.48) | CES2CES1CYP2C19 | |
| SCHEMBL22042217 | 0.72 | HRH1 (0.44) | HRH1CES2CES1HTR2ATAAR1 | |
| SCHEMBL5509988 | 0.70 | L3MBTL1 (0.40) | CA2CA1CA9CA5ACA12 | |
| SCHEMBL4204978 | 0.70 | CA1 (0.50) | CA2CA1CA9CA5AGBA1 | |
| SCHEMBL4450297 | 0.70 | HRH1 (0.41) | HRH1CES2CES1HTR2ATAAR1 | |
| SCHEMBL9789913 | 0.69 | HTR2A (0.65) | HRH1HTR2ATAAR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381132-B1 | Imidazopyridazines, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5202324-A | Bronchodilators | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5155108-A | Imidazopyridazines and use as antiasthmatic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| CN-1047290-A | Imidazopyridazine and preparation thereof and anticaustic | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1990-11-28 | — | — | CN | disclosed |
| EP-0381132-A1 | Imidazopyridazines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |