Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28160684 | 0.88 | HDAC3 (0.47) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR | |
| SCHEMBL7406300 | 0.84 | ALDH1A1 (0.47) | CYP2D6CYP2C19ALDH1A1CES2CES1 | |
| SCHEMBL3674189 | 0.80 | CYP2D6 (0.54) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR | |
| SCHEMBL22042211 | 0.79 | HRH1 (0.46) | TSHRCES2CES1 | |
| SCHEMBL27305718 | 0.79 | CYP2C19 (0.48) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR | |
| SCHEMBL777871 | 0.78 | GABBR2 (0.53) | CYP2D6CYP2C19CES2CES1CPA3 | |
| SCHEMBL14360103 | 0.78 | GABBR2 (0.53) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR | |
| SCHEMBL26269478 | 0.78 | TAAR1 (0.53) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR | |
| SCHEMBL29756122 | 0.77 | CYP3A4 (0.48) | CYP2D6CYP2C19ALDH1A1TSHRPOLB | |
| SCHEMBL8107873 | 0.77 | RIPK1 (0.52) | CYP2D6CYP2C19ALDH1A1CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033635-A1 | Short-chain fatty acid derivatives for treating pruritus | Asan Laboratories Company (Cayman) Limited (CN) | 2009-03-11 | — | — | EP | claimed |
| US-20080107646-A1 | Administering phenylbutyric acid derivative and pharmaceutically acceptable carrier | Sunny Pharmtech Inc. (TW) | 2008-05-08 | — | — | US | claimed |
| US-6403646-B1 | ADMINISTERING PHENYLBUTYRIC ACID OR DERIVATIVES TO TREAT LIVER DISEASE AND EMPHYSEMA CAUSED BY PROTEASE INHIBITOR TYPE Z MUTATION; STIMULATES SECRETION WITHOUT INCREASING SYNTHESIS OF PROTEIN | PERLMUTTER DAVID H (US) | 2002-06-11 | — | — | US | claimed |
| US-8846039-B2 | Method for ameliorating pruritus | ASAN LABORATORIES COMPANY (CAYMAN), LIMITED (TW) | 2014-09-30 | — | — | US | disclosed |
| CN-101380317-B | Pharmaceutical composition for relieving pruritus | CAYMAN ISLAND SHANGANSHENG DEV PHARMACEUTICAL CO LTD | 2010-12-08 | — | — | CN | disclosed |
| EP-2033635-A1 | Short-chain fatty acid derivatives for treating pruritus | Asan Laboratories Company (Cayman) Limited (CN) | 2009-03-11 | — | — | EP | disclosed |
| CN-101380317-A | Pharmaceutical composition for relieving pruritus | CAYMAN ISLAND SHANGANSHENG DEV (CN) | 2009-03-11 | — | — | CN | disclosed |
| EP-2030616-A1 | Short-chain fatty acid derivatives for treating pruritus | Asan Laboratories Company (Cayman) Limited (CN) | 2009-03-04 | — | — | EP | disclosed |
| US-20080107646-A1 | Administering phenylbutyric acid derivative and pharmaceutically acceptable carrier | Sunny Pharmtech Inc. (TW) | 2008-05-08 | — | — | US | disclosed |
| US-6403646-B1 | ADMINISTERING PHENYLBUTYRIC ACID OR DERIVATIVES TO TREAT LIVER DISEASE AND EMPHYSEMA CAUSED BY PROTEASE INHIBITOR TYPE Z MUTATION; STIMULATES SECRETION WITHOUT INCREASING SYNTHESIS OF PROTEIN | PERLMUTTER DAVID H (US) | 2002-06-11 | — | — | US | disclosed |
| CN-1134705-A | Peptidyl compounds and their therapeutic use as inhibitors of metalloproteinases | CHIROSCIENCE LTD (GB) | 1996-10-30 | — | — | CN | disclosed |
| US-4808741-A | Process for preparing carboxyalkyl dipeptides | TORCAN CHEMICAL LTD. (CA) | 1989-02-28 | — | — | US | disclosed |
| US-4141734-A | SUBSTITUTED ORGANIC DI- OR TRISULFIDE ANTIDEPOSIT AGENTS | CIBA-GEIBY AG (CH) | 1979-02-27 | — | — | US | disclosed |