Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 4/20 | 0.45 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212226 | 0.96 | NQO1 (0.47) | NQO1PGAM1TSHRNFKB1PKM | |
| SCHEMBL11161693 | 0.85 | NQO1 (0.61) | NQO1TSHRPKMMEN1KMT2A | |
| SCHEMBL7357932 | 0.82 | NQO1 (0.64) | NQO1TSHRPKMMEN1KMT2A | |
| SCHEMBL7356934 | 0.81 | NQO1 (0.63) | NQO1PKMGAASMN1; SMN2KDM4E | |
| SCHEMBL7354114 | 0.81 | NQO1 (0.63) | NQO1PKMGAASMN1; SMN2KDM4E | |
| SCHEMBL7357238 | 0.81 | NQO1 (0.63) | NQO1PKMGAASMN1; SMN2KDM4E | |
| SCHEMBL7350101 | 0.81 | NQO1 (0.63) | NQO1PKMGAASMN1; SMN2KDM4E | |
| SCHEMBL7357697 | 0.81 | NQO1 (0.63) | NQO1PKMGAASMN1; SMN2KDM4E | |
| SCHEMBL7358532 | 0.78 | NFKB1 (0.43) | NQO1NFKB1NPC1RAB9AMEN1 | |
| SCHEMBL9203833 | 0.77 | NQO1 (0.40) | NQO1PGAM1PKMRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |