SCHEMBL9205541

SCHEMBL9205541

Cc1ccc(C(O)(Cn2ccnc2)c2ccc(-c3ccncc3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 8/20 0.47
CYP11B2 P19099 7/20 0.47
CYP19A1 P11511 3/20 0.47
QPCT Q16769 2/20 0.41
FDPS P14324 2/20 0.39
KIF11 P52732 1/20 0.39
GGPS1 O95749 3/20 0.38
LMNA P02545 2/20 0.38
BTN3A1 O00481 1/20 0.38
CA12 O43570 1/20 0.38
CA2 P00918 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
MMP8 P22894 1/20 0.38
MMP14 P50281 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CYP17A1 P05093 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9202390 0.88 KIF11 (0.53) CYP11B1CYP11B2CYP19A1QPCTFDPS
SCHEMBL9202987 0.86 CYP11B1 (0.48) CYP11B1CYP11B2CYP19A1CYP17A1
SCHEMBL9202252 0.86 CYP17A1 (0.48) CYP11B1CYP11B2CYP19A1QPCTKIF11
SCHEMBL9199981 0.86 CYP11B1 (0.46) CYP11B1CYP11B2CYP19A1QPCT
SCHEMBL9205856 0.85 CYP11B1 (0.52) CYP11B1CYP11B2CYP19A1FDPSGGPS1
SCHEMBL9210780 0.82 HTT (0.47) CYP19A1
SCHEMBL11107776 0.82 CYP11B1 (0.65) CYP11B1CYP11B2CYP19A1QPCTCYP17A1
SCHEMBL11019246 0.82 CYP11B1 (0.50) CYP11B1CYP11B2CYP19A1QPCTFDPS
SCHEMBL9668598 0.79 CYP11B1 (0.47) CYP11B1CYP11B2CYP19A1QPCTLMNA
SCHEMBL11023652 0.79 CYP11B1 (0.69) CYP11B1CYP11B2CYP19A1QPCTFDPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0513149-B1 PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY DU PONT MERCK PHARMA (US) 1995-12-13 EP claimed
EP-0513149-A1 PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY. DU PONT MERCK PHARMA (US) 1992-11-19 EP claimed
US-5049570-A Pyridylphenyl nitrogen heterocycle-substituted carbinols and derivatives thereof with anti-inflammatory activity DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-09-17 US claimed
WO-1991011445-A1 PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-08-08 WO claimed
EP-0513149-B1 PYRIDYLPHENYL NITROGEN HETEROCYCLE-SUBSTITUTED CARBINOLS AND DERIVATIVES THEREOF WITH ANTI-INFLAMMATORY ACTIVITY DU PONT MERCK PHARMA (US) 1995-12-13 EP disclosed
US-5049570-A Pyridylphenyl nitrogen heterocycle-substituted carbinols and derivatives thereof with anti-inflammatory activity DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-09-17 US disclosed