Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | GSR | P00390 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL4417968 | 1.00 | CA5A (0.35) | CA5ACA5BPTGS1PTGS2GSR | |
| SCHEMBL14369217 | 0.93 | — | — | |
| SCHEMBL15570489 | 0.93 | — | — | |
| Nitric Acid SCHEMBL23270365 | 0.76 | — | — | |
| SCHEMBL15570344 | 0.76 | — | — | |
| SCHEMBL7374379 | 0.75 | — | — | |
| Nitric Acid SCHEMBL8846584 | 0.75 | CA5A (0.40) | CA5ACA5BGSR | |
| SCHEMBL11669919 | 0.74 | PTGS1 (0.33) | PTGS1PTGS2GSR | |
| Nitric Acid SCHEMBL28858089 | 0.74 | ALDH1A1 (0.56) | CA5ACA5B | |
| SCHEMBL14476657 | 0.74 | PTGS1 (0.33) | PTGS1PTGS2GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506434-B1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | SANKYO CO (JP) | 1995-02-22 | — | — | EP | disclosed |
| US-5356918-A | Oxazolidinone compounds and method of using the same as a vasodilator | SANKYO COMPANY, LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| US-5298516-A | Treatment of cardiovascular disorders, angina | SANKYO COMPANY, LIMITED (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0506434-A1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | Sankyo Company Limited (JP) | 1992-09-30 | — | — | EP | disclosed |
| US-4612313-A | Pharmaceutical phenylacetonitrile derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1986-09-16 | — | — | US | disclosed |
| EP-0175249-A2 | Phenylacetonitrile derivatives | Roche Diagnostics GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |