Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7538817 | 0.80 | ACHE (0.38) | ACHEMETAP1 | |
| SCHEMBL3054005 | 0.67 | ACHE (0.66) | ACHEMETAP1TSHR | |
| SCHEMBL16691536 | 0.67 | ACHE (0.66) | ACHEMETAP1TSHR | |
| SCHEMBL12857531 | 0.63 | ACHE (0.50) | ACHEMETAP1TSHR | |
| SCHEMBL11879940 | 0.62 | MEN1 (0.34) | — | |
| SCHEMBL29689764 | 0.61 | KMT2A (0.50) | — | |
| SCHEMBL278741 | 0.61 | KMT2A (0.50) | — | |
| SCHEMBL6885858 | 0.61 | CYP19A1 (0.49) | ACHETSHR | |
| SCHEMBL30742814 | 0.61 | MAOB (0.33) | — | |
| SCHEMBL15245116 | 0.61 | MEN1 (0.55) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319073-B1 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME (GB) | 1995-08-23 | — | — | EP | disclosed |
| US-4927819-A | ANTICONVULSANT, PREVENTION OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 1990-05-22 | — | — | US | disclosed |
| EP-0319073-A2 | Cyclo-octane neuroprotective agents | MERCK SHARP & DOHME LTD. (GB) | 1989-06-07 | — | — | EP | disclosed |