Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | METAP1 | P53582 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205807 | 0.80 | ACHE (0.41) | ACHEMETAP1 | |
| SCHEMBL11879940 | 0.75 | MEN1 (0.34) | MAOACES1SMN1; SMN2 | |
| SCHEMBL989079 | 0.72 | IDO1 (0.39) | MAOAMAOBSMN1; SMN2ALDH1A1 | |
| SCHEMBL460544 | 0.64 | GAA (0.36) | — | |
| SCHEMBL342296 | 0.62 | ANPEP (0.38) | ACHEMAOAMAOB | |
| SCHEMBL9211824 | 0.62 | CYP19A1 (0.35) | ACHEMAOACYP2A6MAOBCES1 | |
| SCHEMBL12857531 | 0.60 | ACHE (0.50) | ACHEMETAP1CES1CYP19A1SMN1; SMN2 | |
| SCHEMBL276262 | 0.59 | MAOA (0.41) | ACHEHTR6MAOACYP2A6MAOB | |
| SCHEMBL3614039 | 0.59 | HTR6 (0.53) | ACHEHTR6MAOACYP2A6MAOB | |
| SCHEMBL13961310 | 0.59 | ACHE (0.59) | ACHEMETAP1MAOACES1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198462-A1 | PROCESS FOR PREPARING A 10,11-METHANODIBENZOSUBERANE DERIVATIVE | ELI LILLY AND COMPANY (US) | 2002-04-24 | — | — | EP | claimed |
| WO-2000075132-A1 | PROCESS FOR PREPARING A 10,11-METHANODIBENZOSUBERANE DERIVATIVE | ELI LILLY AND COMPANY (US) | 2000-12-14 | — | — | WO | claimed |
| EP-1198462-A1 | PROCESS FOR PREPARING A 10,11-METHANODIBENZOSUBERANE DERIVATIVE | ELI LILLY AND COMPANY (US) | 2002-04-24 | — | — | EP | disclosed |
| WO-2000075132-A1 | PROCESS FOR PREPARING A 10,11-METHANODIBENZOSUBERANE DERIVATIVE | ELI LILLY AND COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |