Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 9/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.34 |
| ▸ | CCND1 | P24385 | 3/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216549 | 0.81 | GAA (0.41) | NPC1POLBCDK4CCND1KDM4E | |
| SCHEMBL6362219 | 0.80 | SLC6A3 (0.40) | NPC1POLBKDM4EALDH1A1HTT | |
| SCHEMBL6362220 | 0.80 | SLC6A3 (0.40) | NPC1POLBKDM4EALDH1A1HTT | |
| SCHEMBL9199100 | 0.80 | PARP1 (0.36) | NPC1POLBCDK4CCND1CDK5 | |
| SCHEMBL9205832 | 0.78 | MEN1 (0.36) | NPC1POLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9217014 | 0.78 | NPC1 (0.36) | NPC1POLBBCHEHTTSMN1; SMN2 | |
| SCHEMBL9215403 | 0.76 | TDP1 (0.36) | NPC1POLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9214646 | 0.76 | POLB (0.35) | NPC1POLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9214640 | 0.76 | PARP1 (0.36) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9217152 | 0.76 | CES1 (0.38) | NPC1POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569457-B1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- [2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-06-14 | — | — | EP | disclosed |
| EP-0569457-A1 | USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992013863-A1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-20 | — | — | WO | disclosed |