Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 6/20 | 0.33 |
| ▸ | CCND1 | P24385 | 6/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | PRKACG | P22612 | 2/20 | 0.33 |
| ▸ | PRKACB | P22694 | 2/20 | 0.33 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700477 | 0.82 | GAA (0.42) | KDM4ENPC1POLBCDK4CCND1 | |
| SCHEMBL9195253 | 0.81 | SLC6A3 (0.38) | PARP1KDM4EALDH1A1NPC1POLB | |
| SCHEMBL9207191 | 0.80 | IMPDH2 (0.35) | PARP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL9206027 | 0.80 | PARP14 (0.37) | KDM4EALDH1A1NPC1POLBCDK4 | |
| SCHEMBL9739157 | 0.79 | PARP1 (0.39) | PARP1KDM4EALDH1A1NPC1POLB | |
| SCHEMBL9268715 | 0.77 | BRD4 (0.35) | PARP1NPC1POLB | |
| SCHEMBL9700348 | 0.77 | CES1 (0.36) | PARP1NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9701779 | 0.76 | NPC1 (0.34) | PARP1NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9201756 | 0.76 | NPC1 (0.48) | KDM4ENPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9701851 | 0.76 | TSHR (0.37) | KDM4EALDH1A1NPC1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682523-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | Roche Diagnostics GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |
| WO-1992015310-A1 | USE OF TRICYCLIC ISOINDOLINONES AS ANTIVIRAL DRUGS, AND NEW, OPTICALLY ACTIVE ISOINDOLINONES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-09-17 | — | — | WO | disclosed |