Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208945 | 0.84 | MAPT (0.37) | MAPTGAAMTNR1AMTNR1BCYP2C19 | |
| SCHEMBL9205414 | 0.77 | MAPT (0.38) | MAPTGAAMTNR1AMTNR1BCYP2C19 | |
| SCHEMBL7862261 | 0.74 | MAPT (0.39) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL9208636 | 0.72 | MEN1 (0.36) | CYP2C19CYP2C9MEN1ALOX15KMT2A | |
| SCHEMBL9212739 | 0.72 | MEN1 (0.35) | MAPTGAACYP2C19CYP2C9MEN1 | |
| SCHEMBL9213981 | 0.71 | KMT2A (0.39) | MAPTCYP2C19CYP2C9MEN1ALOX15 | |
| SCHEMBL7860961 | 0.69 | MMP2 (0.34) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL7861006 | 0.69 | MAPT (0.38) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL9205054 | 0.67 | MEN1 (0.38) | CYP2C19CYP2C9MEN1ALOX15KMT2A | |
| SCHEMBL9211058 | 0.67 | CACNA1C (0.38) | MAPTGAACYP2C19CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506434-B1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | SANKYO CO (JP) | 1995-02-22 | — | — | EP | claimed |
| US-5298516-A | Treatment of cardiovascular disorders, angina | SANKYO COMPANY, LIMITED (JP) | 1994-03-29 | — | — | US | claimed |
| EP-0506434-A1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | Sankyo Company Limited (JP) | 1992-09-30 | — | — | EP | claimed |
| EP-0506434-B1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | SANKYO CO (JP) | 1995-02-22 | — | — | EP | disclosed |
| US-5356918-A | Oxazolidinone compounds and method of using the same as a vasodilator | SANKYO COMPANY, LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| US-5298516-A | Treatment of cardiovascular disorders, angina | SANKYO COMPANY, LIMITED (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0506434-A1 | Thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators | Sankyo Company Limited (JP) | 1992-09-30 | — | — | EP | disclosed |