Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204734 | 0.84 | PTGS1 (0.53) | PTGS2PTGS1ALDH1A1MAPT | |
| SCHEMBL8953949 | 0.84 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL9210879 | 0.83 | PTGS2 (0.62) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8953830 | 0.83 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL9203460 | 0.83 | PTGS1 (0.52) | PTGS2PTGS1MAPT | |
| SCHEMBL9089661 | 0.83 | PTGS1 (0.74) | PTGS2PTGS1ABCB11 | |
| SCHEMBL8645136 | 0.82 | PTGS1 (0.51) | PTGS2PTGS1ALDH1A1MAPT | |
| SCHEMBL8639378 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1ALDH1A1MAPT | |
| SCHEMBL5149168 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL9206762 | 0.82 | PTGS2 (0.54) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |