Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204734 | 0.88 | PTGS1 (0.53) | PTGS1PTGS2MAPTCA9POLB | |
| SCHEMBL8639378 | 0.85 | PTGS2 (0.53) | PTGS1PTGS2MAPTCA9POLB | |
| SCHEMBL9203460 | 0.83 | PTGS1 (0.52) | PTGS1PTGS2MAPTCA9POLB | |
| SCHEMBL9089661 | 0.83 | PTGS1 (0.74) | PTGS1PTGS2CA9LMNA | |
| SCHEMBL27556627 | 0.83 | PTGS2 (0.57) | PTGS1PTGS2CA9 | |
| SCHEMBL9206905 | 0.82 | PTGS2 (0.52) | PTGS1PTGS2MAPTALDH1A1 | |
| SCHEMBL8638380 | 0.82 | RPA1 (0.55) | PTGS1PTGS2CA9SMN1; SMN2KDM4E | |
| SCHEMBL9201550 | 0.82 | PTGS2 (0.49) | PTGS1PTGS2MAPTCA9POLB | |
| SCHEMBL8199109 | 0.82 | SMN1; SMN2 (0.50) | PTGS1PTGS2MAPTCA9SMN1; SMN2 | |
| SCHEMBL9201561 | 0.81 | CA9 (0.59) | PTGS1PTGS2MAPTCA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |