Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676771 | 0.80 | ALDH1A1 (0.36) | KDM4EDAO | |
| SCHEMBL7677858 | 0.69 | PDE4A (0.40) | DAO | |
| SCHEMBL7683645 | 0.69 | CNR2 (0.33) | DAO | |
| SCHEMBL7685825 | 0.69 | CNR2 (0.40) | DAO | |
| SCHEMBL7682145 | 0.65 | DAO (0.42) | DAO | |
| SCHEMBL7684492 | 0.64 | CYP1A2 (0.38) | DAO | |
| SCHEMBL7677722 | 0.63 | HCAR1 (0.36) | DAO | |
| SCHEMBL7681735 | 0.63 | KMT2A (0.48) | DAO | |
| SCHEMBL7683613 | 0.62 | SMN1; SMN2 (0.41) | KDM4EDAO | |
| SCHEMBL7686410 | 0.62 | CYP1A2 (0.54) | DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664803-A1 | N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008989-A1 | N-ARYLHETEROARYLALKYL 1-CYCLOALKYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1994-04-28 | — | — | WO | disclosed |