Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209545 | 0.86 | AOC3 (0.66) | AOC3PTGS2PTGS1CHRNA7MALT1 | |
| SCHEMBL6341661 | 0.85 | PTGS2 (0.82) | PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL9201802 | 0.84 | MALT1 (0.53) | PTGS2PTGS1EPHX2CHRNA7MALT1 | |
| SCHEMBL9055103 | 0.83 | AOC3 (0.64) | AOC3PTGS2PTGS1CHRNA7MEN1 | |
| SCHEMBL9210924 | 0.82 | AOC3 (0.70) | AOC3PTGS2PTGS1CHRNA7MEN1 | |
| SCHEMBL9203245 | 0.82 | MEN1 (0.70) | AOC3PTGS2PTGS1CHRNA7MEN1 | |
| SCHEMBL9206313 | 0.82 | AOC3 (0.61) | AOC3PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL3866718 | 0.82 | PTGS2 (0.82) | AOC3PTGS2PTGS1CHRNA7MEN1 | |
| SCHEMBL9206453 | 0.82 | PTGS2 (0.67) | AOC3PTGS2PTGS1EPHX2CHRNA7 | |
| SCHEMBL9199556 | 0.82 | AOC3 (0.65) | AOC3PTGS2PTGS1CHRNA7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |