Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9207745 | 0.84 | AOC3 (0.60) | MALT1PTGS2PTGS1EPHX2MEN1 | |
| SCHEMBL9204760 | 0.82 | KMT2A (0.72) | PTGS2MEN1KMT2AATMCHRNA7 | |
| SCHEMBL9204658 | 0.82 | KMT2A (0.72) | PTGS2MEN1KMT2AATMCHRNA7 | |
| SCHEMBL3865146 | 0.81 | PTGS2 (0.69) | MALT1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL9207571 | 0.81 | PTGS2 (0.58) | MALT1PTGS2PTGS1EPHX2MEN1 | |
| SCHEMBL9209766 | 0.81 | MEN1 (0.56) | MALT1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL9207456 | 0.81 | KMT2A (0.59) | MALT1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL9199551 | 0.81 | MEN1 (0.56) | MALT1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL9208842 | 0.79 | MALT1 (0.65) | MALT1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL9201596 | 0.79 | MALT1 (0.65) | MALT1PTGS2MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |