Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 4/20 | 0.75 |
| ▸ | FAAH | O00519 | 4/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.56 |
| ▸ | RPA1 | P27694 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199132 | 0.91 | CA9 (0.80) | CA9FAAHCHRNA7HTTL3MBTL1 | |
| SCHEMBL9054421 | 0.90 | CA9 (0.65) | CA9FAAHCHRNA7RPA1PTGS2 | |
| SCHEMBL9350647 | 0.87 | CA9 (0.71) | CA9FAAHCHRNA7RPA1MALT1 | |
| SCHEMBL9210890 | 0.87 | CA9 (0.74) | CA9FAAHCHRNA7HTTL3MBTL1 | |
| SCHEMBL9203320 | 0.87 | CA9 (0.84) | CA9FAAHCHRNA7HTTL3MBTL1 | |
| SCHEMBL14504353 | 0.86 | CA9 (0.61) | CA9FAAHCHRNA7RPA1PTGS2 | |
| SCHEMBL27333015 | 0.86 | RPA1 (0.72) | CA9CHRNA7RPA1PTGS2PTGS1 | |
| SCHEMBL9103432 | 0.85 | CA9 (0.72) | CA9FAAHCHRNA7HTTL3MBTL1 | |
| SCHEMBL9201580 | 0.85 | CA9 (0.59) | CA9FAAHCHRNA7RPA1PTGS2 | |
| SCHEMBL9353410 | 0.85 | CHRNA7 (0.72) | CA9FAAHCHRNA7RPA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |