SCHEMBL9208296

SCHEMBL9208296

COC1(c2ccc(Sc3cccc4c3N(C)C(=O)CC4)s2)CCOCC1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.48
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9206180 0.89 ALOX5 (0.38) ALOX5
SCHEMBL8554746 0.80 ALOX5 (0.73) ALOX5CYP11B2
SCHEMBL9203608 0.77 ALOX5 (0.31) ALOX5
SCHEMBL8556671 0.76 MAP2K1 (0.32)
SCHEMBL9201657 0.76 ALOX5 (0.41) ALOX5
SCHEMBL9083889 0.70 ALOX5 (0.63) ALOX5CYP11B2
SCHEMBL9086220 0.70 ALOX5 (0.58) ALOX5
SCHEMBL9086298 0.67 ALOX5 (0.40) ALOX5
SCHEMBL9084328 0.67 ALOX5 (0.52) ALOX5
SCHEMBL9086658 0.67 ALOX5 (0.39) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462812-B1 Pyran derivatives as inhibitors of 5-lipoxygenase ZENECA LTD (GB) 1995-12-06 EP claimed