Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 1/20 | 0.59 |
| ▸ | NSD2 | O96028 | 3/20 | 0.44 |
| ▸ | FGB | P02675 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | BLM | P54132 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9198168 | 0.99 | TOP2B (0.58) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL7207025 | 0.92 | TOP2B (0.68) | TOP2BNSD2FGBMMP14NQO1 | |
| Hydrochloric Acid SCHEMBL9205570 | 0.91 | TOP2B (0.67) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL9200470 | 0.87 | HTT (0.48) | TOP2BNSD2FGBMMP14NQO1 | |
| Hydrochloric Acid SCHEMBL9205563 | 0.86 | HTT (0.47) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL9202338 | 0.79 | SMN1; SMN2 (0.51) | NSD2MAPK1LMNAMEN1BLM | |
| SCHEMBL9206570 | 0.78 | TOP1 (0.53) | MEN1KMT2AHTTSMN1; SMN2TOP2A | |
| SCHEMBL9207090 | 0.78 | HTT (0.55) | TOP2BNSD2FGBMMP14NQO1 | |
| Hydrochloric Acid SCHEMBL9202443 | 0.77 | TOP1 (0.52) | HTTSMN1; SMN2TOP2AHIF1AGAA | |
| Hydrochloric Acid SCHEMBL9205298 | 0.76 | HTT (0.54) | TOP2BNSD2FGBMMP14NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497809-B1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER MANNHEIM ITALIA (IT) | 1995-06-28 | — | — | EP | disclosed |
| US-5162320-A | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| EP-0497809-A1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES. | BOEHRINGER MANNHEIM ITALIA (IT) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006540-A1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-05-16 | — | — | WO | disclosed |