Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 1/20 | 0.68 |
| ▸ | NSD2 | O96028 | 3/20 | 0.50 |
| ▸ | FGB | P02675 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | BLM | P54132 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | TOP2A | P11388 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9205570 | 0.98 | TOP2B (0.67) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL9208748 | 0.92 | TOP2B (0.59) | TOP2BNSD2FGBMMP14NQO1 | |
| Hydrochloric Acid SCHEMBL9198168 | 0.91 | TOP2B (0.58) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL9207090 | 0.84 | HTT (0.55) | TOP2BNSD2FGBMMP14NQO1 | |
| Hydrochloric Acid SCHEMBL9205298 | 0.83 | HTT (0.54) | TOP2BNSD2FGBMMP14NQO1 | |
| Ametantrone SCHEMBL3344151 | 0.81 | TOP2B (1.00) | TOP2BNSD2FGBMMP14NQO1 | |
| Ametantrone SCHEMBL29723071 | 0.81 | TOP2B (1.00) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL9210182 | 0.81 | TOP1 (0.52) | TOP2BMAPK1MEN1BLMKMT2A | |
| Hydrochloric Acid SCHEMBL11041980 | 0.80 | TOP2B (0.97) | TOP2BNSD2FGBMMP14NQO1 | |
| SCHEMBL3746887 | 0.79 | TOP2B (0.56) | TOP2BNSD2FGBMMP14NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710689-B1 | Polymeric antitumor agents | WYETH CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5609867-A | POLYAMIDES FROM DIAMINE MONOMERS CONTAINING ANTHRAQUINONE, ANTHRAPYRAZOLE, AZA-ANTHRAQUINONE, AND DIAZA-ANTHRAQUINONE RINGS | AMERICAN CYANAMID COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0710689-A2 | Polymeric antitumor agents | American Cyanamid Company (US) | 1996-05-08 | — | — | EP | disclosed |
| EP-0497809-B1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER MANNHEIM ITALIA (IT) | 1995-06-28 | — | — | EP | disclosed |
| US-5162320-A | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| EP-0497809-A1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES. | BOEHRINGER MANNHEIM ITALIA (IT) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006540-A1 | 1,4-BIS(ALKYLAMINO)-2,3-DIAZA-ANTHRACENE-9,10-DIONES | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-05-16 | — | — | WO | disclosed |