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Sugi Predict / Compounds / SCHEMBL9208901

SCHEMBL9208901

SCHEMBL9208901

COCC1CN(c2ccc3ccc(OC)cc3c2)C(=O)O1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GRM2 Q14416 12/20 0.56
▸ SIGMAR1 Q99720 2/20 0.46
▸ HTR1A P08908 1/20 0.45
▸ HTR1D P28221 1/20 0.45
▸ HTR1B P28222 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6269776 0.89 GRM2 (0.56) GRM2
SCHEMBL9210042 0.87 GRM2 (0.52) GRM2
SCHEMBL9206566 0.87 GRM2 (0.47) GRM2
SCHEMBL9214029 0.86 GRM2 (0.48) GRM2
SCHEMBL9209486 0.85 SIGMAR1 (0.49) GRM2SIGMAR1
SCHEMBL9205112 0.85 GRM2 (0.53) GRM2
SCHEMBL8566870 0.85 GRM2 (0.53) GRM2
SCHEMBL9211629 0.84 GRM2 (0.49) GRM2
SCHEMBL9211870 0.84 GRM2 (0.49) GRM2
SCHEMBL9204446 0.84 GRM2 (0.49) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0425209-B1 Naphthyloxazolidone derivatives TANABE SEIYAKU CO (JP) 1995-05-10 — — EP disclosed
US-5332754-A Antidepressant TANABE SEIYAKU CO., LTD. (JP) 1994-07-26 — — US disclosed
US-5182296-A Antidepressants TANABE SEIYAKY CO., LTD. (JP) 1993-01-26 — — US disclosed
EP-0425209-A2 Naphthyloxazolidone derivatives TANABE SEIYAKU CO., LTD. (JP) 1991-05-02 — — EP disclosed
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