Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688245 | 0.83 | LMNA (0.54) | — | |
| SCHEMBL9209194 | 0.82 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2GPBAR1ALOX5CYP1A2 | |
| SCHEMBL9202167 | 0.81 | GPBAR1 (0.53) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE4A | |
| SCHEMBL9209065 | 0.80 | CYSLTR1 (0.63) | CYSLTR1CYSLTR2GPBAR1ALOX5CYP1A2 | |
| SCHEMBL10635186 | 0.78 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1ALOX5CYP1A2 | |
| SCHEMBL3683044 | 0.77 | NPSR1 (0.42) | — | |
| SCHEMBL10635332 | 0.77 | CYSLTR1 (0.70) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL9199452 | 0.75 | GPBAR1 (0.59) | CYSLTR1CYSLTR2GPBAR1CYP1A2PDE10A | |
| SCHEMBL9209068 | 0.75 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE4A | |
| SCHEMBL6706690 | 0.75 | PTPN1 (0.44) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-B1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5290788-A | Indole derivatives as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1994-03-01 | — | — | US | disclosed |