Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209304 | 1.00 | HTR1A (0.45) | HTR1AADRA1ANAMPTNPC1RAB9A | |
| SCHEMBL9213906 | 0.88 | HTR1A (0.48) | HTR1AADRA1ANAMPTNPC1RAB9A | |
| SCHEMBL9213912 | 0.88 | HTR1A (0.48) | HTR1AADRA1ANAMPTNPC1RAB9A | |
| SCHEMBL9218662 | 0.87 | NAMPT (0.44) | HTR1AADRA1ANAMPT | |
| SCHEMBL9213866 | 0.87 | NAMPT (0.44) | HTR1AADRA1ANAMPT | |
| SCHEMBL9217875 | 0.84 | NAMPT (0.47) | HTR1AADRA1ANAMPTP2RX7 | |
| SCHEMBL9217879 | 0.84 | NAMPT (0.47) | HTR1AADRA1ANAMPTP2RX7 | |
| SCHEMBL9219153 | 0.79 | HTR1A (0.47) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9216880 | 0.79 | HTR1A (0.47) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9216629 | 0.77 | NPC1 (0.43) | HTR1AADRA1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |