Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219153 | 1.00 | HTR1A (0.47) | HTR1AADRA1ANPC1TP53RAB9A | |
| SCHEMBL9209299 | 0.79 | HTR1A (0.45) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9209304 | 0.79 | HTR1A (0.45) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9217498 | 0.78 | ABCC9 (0.51) | HTR1AADRA1AALDH1A1GLA | |
| SCHEMBL9217496 | 0.78 | ABCC9 (0.51) | HTR1AADRA1AALDH1A1GLA | |
| SCHEMBL9213912 | 0.77 | HTR1A (0.48) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9213906 | 0.77 | HTR1A (0.48) | HTR1AADRA1ANPC1RAB9A | |
| SCHEMBL9213866 | 0.76 | NAMPT (0.44) | HTR1AADRA1ASMN1; SMN2KDM4EGAA | |
| SCHEMBL9216624 | 0.76 | NPC1 (0.43) | HTR1AADRA1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9216629 | 0.76 | NPC1 (0.43) | HTR1AADRA1ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |