Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | NQO1 | P15559 | 3/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310481 | 0.78 | VKORC1 (0.82) | VKORC1CYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL32659670 | 0.78 | VKORC1 (0.82) | VKORC1CYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL7897821 | 0.78 | VKORC1 (0.67) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL8868322 | 0.76 | VKORC1 (0.69) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL7352666 | 0.74 | VKORC1 (0.62) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL7349603 | 0.73 | VKORC1 (1.00) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL14078661 | 0.73 | NQO1 (0.73) | VKORC1CYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL7352670 | 0.72 | LMNA (0.60) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL25198895 | 0.71 | VKORC1 (0.58) | VKORC1MEN1KMT2ACYP2C9NQO1 | |
| SCHEMBL9209760 | 0.71 | LMNA (0.53) | VKORC1MEN1KMT2ACYP2C9NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |