SCHEMBL9209841

SCHEMBL9209841

Cc1ccccc1C(=O)n1c(-c2ccc(Cl)cc2)c(C#N)c(Br)c1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 3/20 0.38
HPGD P15428 5/20 0.35
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 4/20 0.35
MAPT P10636 3/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
ELANE P08246 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
HTT P42858 2/20 0.33
GRIA2 P42262 1/20 0.33
GRIA4 P48058 1/20 0.33
LMNA P02545 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
PLAU P00749 1/20 0.33
ENPP3 O14638 1/20 0.33
ALPL P05186 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9217907 0.86 CNR2 (0.37) HPGDALDH1A1MAPTKMT2AMEN1
SCHEMBL8404970 0.85 ABCB1 (0.37) MGLLHPGDKDM4EALDH1A1MAPT
SCHEMBL9218224 0.84 MEN1 (0.37) MGLLHPGDKDM4EALDH1A1MAPT
SCHEMBL9218441 0.83 MGLL (0.37) MGLLHPGDKDM4EALDH1A1MAPT
SCHEMBL9423599 0.82 KDM4E (0.38) HPGDKDM4EALDH1A1MAPTKMT2A
SCHEMBL9211327 0.81 MAPT (0.39) HPGDKDM4EALDH1A1MAPTKMT2A
SCHEMBL9423704 0.81 MEN1 (0.36) KDM4EALDH1A1MAPTKMT2AMEN1
SCHEMBL9212060 0.81 ALDH1A1 (0.36) HPGDKDM4EALDH1A1MAPTKMT2A
SCHEMBL9423419 0.80 ALDH1A1 (0.38) MGLLHPGDKDM4EALDH1A1MAPT
SCHEMBL9215790 0.80 MGLL (0.42) MGLLHPGDKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484614-B1 N-acylated arylpyrroles useful as insecticidal, acaricidal, nematicidal and molluscicidal agents AMERICAN CYANAMID CO (US) 1995-05-24 EP claimed
US-5328928-A Miticides, nematocides, fungicides or molluscicides AMERICAN CYANAMID COMPANY (US) 1994-07-12 US claimed
US-5328928-A Miticides, nematocides, fungicides or molluscicides AMERICAN CYANAMID COMPANY (US) 1994-07-12 US disclosed