Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 4/20 | 0.35 |
| ▸ | ATIC | P31939 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050424 | 0.91 | GART (0.48) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9050434 | 0.91 | GART (0.48) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9048289 | 0.90 | GART (0.44) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9048299 | 0.90 | GART (0.44) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9215054 | 0.88 | DHFR (0.37) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9211571 | 0.87 | GART (0.52) | GARTDHFRATIC | |
| SCHEMBL10570448 | 0.87 | GART (0.52) | GARTDHFRATIC | |
| SCHEMBL10479162 | 0.86 | KDM4E (0.37) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10479164 | 0.86 | KDM4E (0.37) | GARTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9215631 | 0.86 | GART (0.35) | GARTKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0344922-A2 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-12-06 | — | — | EP | disclosed |
| US-4871746-A | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |